WebMay 1, 2024 · The TROP2-directed antibody–drug conjugate datopotamab deruxtecan may be active in patients with advanced or metastatic non–small cell lung cancer, according to preliminary findings. In a phase I trial, the agent elicited responses in almost a quarter of patients and had manageable side effects. Preliminary results suggest that the TROP2 ... WebJan 1, 2024 · The current standard-of-care for the treatment of advanced non-small cell lung cancer (NSCLC) incorporates targeted therapies, immune-checkpoint inhibitors (ICI) and systemic chemotherapy. Antibody-drug conjugates (ADC) are a class of anti-cancer therapy capable of transporting cytotoxic drugs directly to tumour cells, thus harnessing the ...
Datopotamab deruxtecan-based combinations show …
WebThe TROP2-directed antibody–drug conjugate datopotamab deruxtecan may be active in patients with advanced or metastatic non–small cell lung cancer, according to preliminary findings. In a phase I trial, the agent elicited responses in almost a quarter of patients and had manageable side effects. durbin senate judiciary committee speech
Datopotamab Deruxtecan-Based Combinations Show Promising …
WebOct 29, 2024 · TROP-2 is a transmembrane glycoprotein. It’s overexpressed on many cancers. It has been associated with increased tumor growth and sometimes increased metastasis. It has been associated with a... WebJul 27, 2024 · TROP2 is a transmembrane glycoprotein that is overexpressed in many cancers including up to 80% of patients with triple-negative breast cancer. 2,3 High TROP2 expression also has been identified in a majority of non-small cell lung cancers. 1 Research indicates that high TROP2 expression is associated with cancer cell growth and … WebQ3W, every 3 weeks; RECIST, Response Evaluation Criteria in Solid Tumors; TNBC, triple-negative breast cancer; TROP2, trophoblast cell-surface antigen 2. a This analysis in the NSCLC cohort was performed 6 months after the last patient received their first dose of study drug on October 6, 2024. durbin recovery