SpletPDIA6 is overexpressed in NSCLC and inhibits cisplatin-induced NSCLC cell apoptosis and autophagy via the MAP4K1/JNK/c-Jun signaling pathway, suggesting that PDIA6 may serve as a biomarker and therapeutic target for NSCLC patients. FUND: National Natural Science Foundation of China and Institutions … Splet18. mar. 2024 · The “two-hits” hypothesis has been the leading theory on NAFLD [ 4 ]. The first hit is the excessive accumulation of fat in hepatocytes, leading to IR. The second hit is the inflammatory response in the liver induced by …
Prevalence trends in non-alcoholic fatty liver disease at the global ...
Splet13. apr. 2024 · Another ER protein, protein disulfide isomerase 6 (PDIA6), is regulated by miR-322 and is upregulated during ER stress by the consecutive downregulation of miRNA, ... and miR-30 were also determined to enhance the pathogenicity of nonalcoholic fatty liver disease (NAFLD) by regulating ER stress . An ER stress–miRNA interaction has also been ... Splet01. sep. 2016 · Non-alcoholic fatty liver disease (NAFLD) is one of the major causes of chronic liver injury, which includes a wide range of clinical pathological symptoms from … northgate rb live
Non-alcoholic fatty liver disease - Latest research and news - Nature
SpletBecause NAFLD causes no symptoms in most cases, it frequently comes to medical attention when tests done for other reasons point to a liver problem. This can happen if your liver looks unusual on ultrasound or if … Splet18. jul. 2024 · The occurrence of nonalcoholic fatty liver disease (NAFLD) is associated with major abnormalities of hepatic lipid metabolism. We propose that lipid abnormalities directly or indirectly contribute to NAFLD, especially fatty acid accumulation, arachidonic acid metabolic disturbance, and ceramide over … Splet01. dec. 2024 · To further explore how the number of β-cells is reduced in Pdia6 mutants, we analyzed the expression of key β-cell genes using qPCR analysis on isolated islets … northgate rbc edmonton transit