WebJul 4, 2016 · Europe PMC is an archive of life sciences journal literature. WebJul 4, 2016 · The field of photopharmacology uses molecular photoswitches to establish control over the action of bioactive molecules. It aims to reduce systemic drug toxicity and the emergence of resistance, while achieving unprecedented precision in treatment. By using small molecules, photopharmacology provides a viable alternative to optogenetics.
Structural Aspects of Photopharmacology: Insight into the ... - PubMed
WebJun 1, 2024 · Photopharmacology has provided drug-like molecules that change their efficacy upon irradiation and allow for the optical control of a wide range of defined biological targets. ... we provide a brief overview of the current state and limitations of PDT and discuss the potential impact of emerging technologies. From phototherapy to … WebPhotopharmacology aims to locally treat diseases and study biological processes with photoresponsive drugs. Herein, easy access to photoswitchable drugs is crucial, which is supported by simple and robust drug modifications. We investigated the possibility of creating drugs that can undergo remote activation and deactivation with light, by … bebi kosename
Emerging Targets in Photopharmacology Request PDF
WebMar 8, 2024 · rational design in photopharmacology taking Escherichia coli dihydrofolate reductase (eDHFR), a relevant drug target for antibiotics, as a model case. Starting from the concept of design−make−test−analyze (DMTA) cycles35 common in early stage drug discovery efforts, we conducted several cycles WebThe selective targeting of telomeric G4 DNA with a dithienylethene ligand and the robust visible-light mediated switching of the G4 ligand binding mode and G-tetrad structure in physiologically-relevant conditions indicate for the first time the potential of G4 to serve as a target for photopharmacological strategies. We report the selective targeting of telomeric … WebJun 19, 2024 · The emerging field of photopharmacology aims to use light as an external stimulus to activate drug molecules, and do so with a high degree of control over the time and place where this happens - a conceptually straightforward task, which in fact requires an interdisciplinary effort across both chemical synthesis and light delivery technology. divoke kone 37