Web本发明提供了一种肺纤维化体外精准模拟方法,随着TGFβ的持续诱导,本模型在体外重现了炎症反应的发生、促纤维化因子的异常累积、纤维化相关标志物的过表达等一系列纤维化进程中的重要分子事件,并在形态学与组织病理学上也呈现了纤维化的典型病理特征。 WebCHIR98014, also known as CT-98014, is a reversible, cell-permeable inhibitor of GSK3α and GSK3β (IC50 = 0.65 and 0.58 nM, respectively). It is inactive against a series of other serine/threonine or tyrosine kinases. Through its effects on GSK3, CHIR98014 stimulates glycogen synthase in cells (EC50 = 106 nM), potentiates insulin-dependent glucose …
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CHIR-98014 GSK-3 Inhibitor MedChemExpress
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